Before physics, pre-aristotle philosophers believed everything could be reduced to tiny atomic particles. They just didn't know how.
These ideas persisted through the 1100s until the dark ages replaced scientific inquiry with superstition and sorcery. The dark age came to an end with the renaissance and the work of one of my historic heartthrobs Giordano Bruno and later, Galileo, the father of experimental science, who would've been given the same treatment had he not recanted his theories under threat of death.
Newton invented calculus to apply new mathematics to study the universal forces of the heavens against the theological zeitgeist which assumed objects moved because of their desire to be reunited with the earth. His laws helped discover the precise location of Neptune, the nature of heat which made possible the industrial revolution through steam engines, which paved Maxwell's equations which are the root for all laser, TV, and generator technology, which paved Einstein's 4-dimensional pythagorum theorem and special relativity, which paved Rutherford's discovery of the atomic nucleus and the eventual and catastrophic Manhattan Project.
The neutrino, the standard model, the large hadron collider and the higgs boson (god particle). All pieces of a puzzle throughout the evolution of physics attempting to marry gravity, light and nuclear forces. The God Equation is physicists' pursuit of solving the symmetry that governs the known universe. String and multiversal bubble theory now outshine classic quantum mechanics as the next horizon to counter theological arguments that if the universe started, it had to be started by a pre-big bang something. The inflation theory of the multiversal bubble reworks this contradiction by supposing big bangs are happening all the time; before, alongside, and after ours, all in a large bubble bath of nirvanic hyperspace.
Understandably, this isn't a compatible explanation for creationists or the like, but the meaning of life is something we have to struggle to understand and appreciate. Having it given to us defeats the purpose of meaning, because if meaning was available for free, it'd be (and is) meaningless.